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Given that p53 activation of the cyclin dependent kinase inhibitorp21 is the most likely p53-effector of cell cycle arrest [24] the Lozano laboratorytested whether loss of mdm-2 could be rescued by crossing the mice to p21 ?/?mice. Individuallyadapted interfaces may be mandatory for thesepatients. 24.4) represents nonkera-tinized stratified squamous epithelium that consists ofapproximately five layers of cells and measures about 50