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Its objective was to determine thenatural history of unruptured aneurysms and has sincechallenged our understanding of aneurysm rupture risk.Surprisingly, the study found that, for aneurysms smallerthan 7 mm and located in selected parts of the anteriorcirculation in patients who had not had a prior aneurys-mal SAH, the risk of subsequent rupture was extremelysmall (0.05% per year in the retrospective arm and a5-year cumulative risk of rupture of 0% in the prospectivearm).

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Interestingly, c-Abl is activated by ATM in response to DNAdamage (reviewed in [132, 133]), raising the possible scenario that ATM and c-Ablmay work in concert to neutralize Mdm2 under certain stress conditions (Fig. (2001) Recognition memory andverbal fluency differentiate probable Alzheimer disease fromsubcortical ischemic vascular dementia. Eachstep has its own unique challenges that must be met.